2019/2020

2021/2022

DM270

DEPARTMENT OF INTERNAL MEDICINE AND THERAPEUTICS

MEDICINE AND SURGERY

PERCORSO COMUNE

3°

1st semester (27/09/2021 - 14/01/2022)

5

Italian

Adequate understanding of principles of Anatomy, Physiology, Biology and Biochemistry.

The aim of the course is to give information on general principles and molecular aspects on how drugs act, drugs discovery and development, targets for drug action and quantitative aspect of drug–receptors interactions, absorption, distribution and excretion of drugs in the body, pharmacokinetics and therapeutic drug monitoring.

General principles and molecular aspects on how drugs act. Drugs discovery and preclinical studies. Clinical studies. Pharmacovigilance. Targets for drug action: receptor proteins (receptors classification and molecular structure of receptors); drug-receptor interactions, drug antagonism. Quantitative aspect of drug–receptors interactions. The movement of the drugs molecules across cell barrier and the adsorption and distribution of drugs in the body. Drug metabolism and first-past effect. Renal excretion of drugs. Biliary excretion and enterohepatic circulation. Pharmacokinetics. Therapeutic drug monitoring. Biotech drugs. Harmful effects of drugs: type of adverse drug reaction, drug toxicity.

Lectures

Goodman and Gilman's The Pharmacological Basis of Therapeutics 13th Edition, New York McGraw-Hill, 2018

Written examination consisting of oral questions, primarily based upon the didactic material covered in the course.

Faculty members are available at times reserved for student visits to provide clarifications about topics included in the course.