MED/04 (GENERAL PATHOLOGY)
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
2nd semester (01/03/2022 - 14/06/2022)
48 lesson hours
Basic notions of biology.
The aim of the course is:
to learn immunology basic notions
to Know the mechanisms of the natural and specific immune response, humoral (antibodies) and cellular (B, T, NK lymphocytes and their receptors)
These notions are extremely useful for the biologist profession.
Constitutive elements of the immune system and immune response (natural, specific, humoral, cellular, primary, secondary). Embryogenesis, phylogeny and evolution of the immune system. Proteins and cells of inflammation. Recognition, processing, antigen presentation and tolerance; immunity effector mechanisms. B lymphocytes and BCR receptor. Structure and function of instruments (isotypes, allotypes, idiotypes). Clonal selection. T lymphocytes and thymic selection: the T receptor (structure and function). The serum complement system (classical and alternative way). The major histocompatibility system (proteins, functions and genes).
Cytokines and interferons. Hypersensitivity and immunodeficiencies (congenital and acquired). Vaccinations. autoimmunity Immunobiology of tumors. Compatibility and transplants (auto, allo, xenon; organ and hematopoietic stem cells).
Reccomended or required readings
Peter Parham "Il sistema immunitario" EDISES; Thao Doan "Le basi dell'immunologia" Zanichelli
Sustainable development goals - Agenda 2030