2021/2022

2022/2023

DM270

CHIM/08 (PHARMACEUTICAL CHEMISTRY)

DEPARTMENT OF MOLECULAR MEDICINE

MEDICAL AND PHARMACEUTICAL TECHNOLOGIES

Farmaceutico:Biotecnologie farmaceutiche per la ricerca e sviluppo

2°

2nd semester (06/03/2023 - 09/06/2023)

3

24 lesson hours

Italian

ORAL TEST

LINCIANO PASQUALE (titolare) - 3 ECTS

Basic knowledge of organic chemistry, pharmacology and Medicinal Chemistry is required.

To provide advanced knowledge on the methodologies and approaches to design and optimize compounds for identifying drug candidates.

The course offers insights on specific topics that play a key role in the drug discovery process.
Drug screening techniques for the drug discovery. Preparation of drug libraries (parallel and combinatorial synthesis, microwave-assisted organic synthesis, flow chemistry).
Several scientific articles will be discussed particularly focussing on communication using a correct scientific terminology.

Teaching methods used in the course include lectures, problem-based learning groups, independent study. Discussion of the lecture topics during class is encouraged.

The Practice of Medicinal Chemistry
4th Edition, Camille Wermuth David Aldous Pierre Raboisson Didier Rognan, ISBN: 9780124172050

Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Edition, Wei Zhang (Editor), Berkeley W. Cue (Editor), Wiley, 2018, ISBN: 978-1-119-28816-9

Microwave Heating: Electromagnetic Fields Causing Thermal and Non-Thermal Effects, Edited by Gennadiy I. Churyumov, IntechOpen, 2021, ISBN: 978-1-83968-227-8, Print ISBN: 978-1-83968-226-1

Scientific articles

The exam includes an oral exam consisting of a discussion of a scientific article, to evaluate the depth of understanding in the topics of the program. It will be also evaluated the ability to speak with propriety of language and organization of the subject exposed.

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