2021/2022

2023/2024

DM270

DEPARTMENT OF CLINICAL-SURGICAL, DIAGNOSTIC AND PEDIATRIC SCIENCES

SCHOOL OF DENTAL MEDICINE

PERCORSO COMUNE

3°

1st semester (02/10/2023 - 02/02/2024)

7

Italian

Knowledge of Cellular and Molecular Biology Biochemistry, Genetics, Physiology, Histology and Anatomy are required for understanding the course.

This course studies the nature of alterations in biological tissues, together with the local and general reactions of the organism and the protective or damaging effects associated with them. General pathology analyses the causes and mechanisms of pathological processes with the decisive aid of the experimental models. This part of the course, considering the most frequent human pathologies, will evaluate the dynamics of cellular injury, analysing cell death such as apoptosis and necrosis, basic lesions (degeneration, inflammation, tumours) and some examples of complex lesions (thrombus and atheroma). Immunology will treat immunity, seen as a generalized reaction of the organism to safeguard its integrity and individuality, particularly focusing on the adaptive Immunity; Immunopathology, referring to deficiencies of the immune response and immunological injury, will consider some of the pathologies relevant to medical practice.

Introduction to the immune system, cells involved in the immune response, the lymphoid system, adaptive Immunity. Recognition of antigens, antibodies and antigens, the Major Histocompatibility Complex (MHC). Antigen recognition, cell cooperation in the antibody response. Blood groups and transfusions. The hypersensitivity. Damaging agents causing human disease. Molecular mechanisms of the pathological processes. The course of Pathology will focus on the dynamics of cellular injury, including cell death such as apoptosis and necrosis, necroptosis and pyroptosis, and the elementary lesions (degenerative diseases, inflammatory processes, immunological lesions, cell growth alterations, in particular malignant tumours) and some examples of complex lesions (thrombus and atheroma).

The course consists of lectures by using PowerPoint presentations projected on the screen, explanations by blackboard and demonstrations with digital microscope in the lecture theatre (optional) on mouth and teeth specimens.

General Pathology - Altucci et al. (Idelson-Gnocchi)
Pathologic basis of disease (Vol. I) - Robbins and Cotran (Elsevier - Masson)
General Pathology - Pontieri et al. (Piccin)
Basic Immunology – Abul K. Abbas, Andrew H. Lichtman - Elsiever
Le difese immunitarie – Quaglino et al., PICCIN
The immune system – Peter Parham, Edises
The books are available for consultation at the Unit of Immunology and Pathology, Via Ferrata 9, Pavia.

The exam consists of a written test aimed at ascertaining the skills acquired in relation to the contents of the course. It includes 10 thematic questions, 8 of Pathology and 2 of Immunology, on the different topics debated during the lectures will be given. The arithmetic mean will determine the final mark. The evaluation considers the degree of depth and understanding of the topics, but also the ability to integrate the knowledge acquired.

Teachers are available for any explanation of the topics covered in the course during office hours.

Goal 4: quality of Education
$lbl_legenda_sviluppo_sostenibile