Enrollment year
2021/2022
Academic discipline
BIO/14 (PHARMACOLOGY)
Department
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
Curriculum
PERCORSO COMUNE
Period
2nd semester (01/03/2022 - 14/06/2022)
Lesson hours
72 lesson hours
Activity type
WRITTEN TEST
Prerequisites
Fundamental notions of cytology and pharmacology
Learning outcomes
Integrated knowledge of some molecular, cellular and functional processes in the central nervous system (CNS).
Acquisition of advanced knowledge of drug-receptor interactions for rational design of novel drugs.
Course contents
Neurochemistry. Molecular and functional aspects of the blood brain barrier (BBB); astrocyte and neuron interplay; energy metabolism, metabolic rate for oxygen and glucose; mitochondrial activity and reactive oxygen species; calcium homeostasis; major inhibitory and excitatory neurotrasmitter systems (synthesis, metabolism, receptors and reuptake); neurodegeneration.
Molecular Neuropharmacology. Drug-receptor theories; drug potency and efficacy; inverse agonism, partial agonism and biased agonists; hormesis; examples of neurotoxins; systems for drug delivery to the central nervous system (CNS); drugs acting on the GABA metabolism; opiates, endogenous oppioids and non steroidal antinflammatory drugs; anesthetic and antiepyleptic drugs.
Teaching methods
Frontal lecturing
Reccomended or required readings
The power point slides in pdf format are provided by the teacher.
Molecular Pharmacology from DNA to drug discovery (Wiley-Blackwell);
Molecular Neuropharmacology, a foundation for Clinical Neuroscience (Nestler EJ, Hyman SE, Malenka RC), third edition.
pdfs of most important paper of the topics.
Assessment methods
written examination: 5 open questions- 2 hours time
Further information
written examination: 5 open questions- 2 hours time
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa