Enrollment year
2018/2019
Academic discipline
BIO/14 (PHARMACOLOGY)
Department
DEPARTMENT OF PUBLIC HEALTH, NEUROSCIENCE, EXPERIMENTAL AND FORENSIC MEDICINE
Course
SPORT AND EXERCISE SCIENCES
Curriculum
PERCORSO COMUNE
Period
(01/03/2021 - 04/06/2021)
Lesson hours
48 lesson hours
Activity type
WRITTEN TEST
Prerequisites
Have basic notions acquired during the courses of Chemistry and Biochemistry of Sport, Human Anatomy and Human Physiology, essential to understand some topics covered in the General Pharmacology course. To take the exam, it is mandatory to have passed the Human Physiology exam.
Learning outcomes
The General Pharmacology course is aimed at acquiring the fundamental principles of the biological effects of drugs from the pharmacodynamic, pharmacokinetic, pharmacometabolic and toxicological aspects. The main pharmacological classes used for therapeutic or doping purposes in sports will also be illustrated.
Course contents
Prof. Vairetti Mariapia:
General principles, drug definition; preclinical and clinical experimentation in pharmacology.
Basic principles of pharmacokinetics.
Routes of administration and absorption of drugs.
Distribution and biotransport processes.
Drug metabolism.
Induction and inhibition of drug metabolising enzymes.
Drug elimination processes.
Presystemic elimination and first pass effect.
Dose-response relationship.
Doses and dose-effect curves.
Therapeutic index and safety margin.
Mechanism of action of drugs.
Structure-action relationship.
Biological targets of drugs.
Classification and structure of receptors.
Quantitative aspects of drug-receptor interaction.
Factors influencing the response to drugs.
Adverse drug reactions.
Prof. Feletti Fausto:
1. Pharmacokinetics and sport
2. Effect of physical exercise on pharmacokinetics
3. Sympathetic system and hormonal axes
4. Exercise and the sympathetic system
5. Effect of physical exercise on the hypothalamus-pituitary-soma axis
6. Amino acids and hypothalamus-pituitary-soma axis
7. Effects of GH abuse
8. Hypothalamic-pituitary-thyroid axis: general information
9. Exercise and thyroid function
10. Hypothalamic-pituitary-gonadal axis: general information
11. Gonadotropins
12. Action of gonadotropins in males
13. Action of gonadotropins in females
14. Metabolic effects of testosterone
15. Metabolic effects of estrogen
16. Pharmacological and toxicological actions of anabolic steroids
17. Hypothalamic-pituitary-adrenal axis: general information
18. Exercise, stress and overtraining
19. Glucocorticoids and exercise
20. Mineralocorticoids and exercise
21. Sweating and management of the hydro-saline balance
22. Exercise and inflammation
23. Cortisones and NSAIDs
24. Emodoping - Doping - Anti-doping laws
Teaching methods
Lectures carried out through presentations (Power Point) projected on the screen and possible further information using the blackboard or with other systems in relation to the COVID-19 emergency.
Reccomended or required readings
D.R. Mottram, Farmaci e Sport. Casa Editrice Ambrosiana 2005.
"Farmacologia"- Rang-Dale.
Assessment methods
Written examination consisting of 30 multiple choice questions primarily based on didactic material covereded in the course, regardless of whether the examination is carried out in the presence or electronically. One point for each right answer.
Further information
The lecturers will provide the presentations in pdf format or in another format and other material of study of the topics discussed.
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa