2020/2021

2021/2022

DM270

BIO/14 (PHARMACOLOGY)

DEPARTMENT OF CHEMESTRY

CHEMISTRY

PERCORSO COMUNE

2°

1st semester (27/09/2021 - 21/01/2022)

6

48 lesson hours

Italian

ORAL TEST

VILLA ROBERTO FEDERICO (titolare) - 6 ECTS

There is no specific cultural preparation requested for foreign students, but the Curriculum Vitae will be analyzed previously, in the perspective of assessing if an adequate background about fundamental disciplines is present.

This course was specifically designed for upper grade (M.Sc.) Chemistry students; in particular, the aim of this Course is to integrate the pharmacological and chemical aspects of drugs with the therapeutic ones, in the perspective of understanding the basic principles of drug actions, allowing a translational approach of future students’ researches. Consequently, this will improve the ability of adequately communicate in a scientific background, also through constructive criticisms and independent opinions.

detailed Program

Drug adsorption, distribution, and elimination are discussed in relation to the molecular effects of the drugs on functional elements of cells, stressing the importance between the chemical structure of the drugs and their pharmacological actions. Chemical pathways of drug metabolism, species, ageing and genetic differences and the time course of drugs in therapy will be also discussed.
In addition, the principles of drug-receptor theory, the dose-response effects, all types of agonist and antagonist drug-receptor interactions, their molecular consequences for the development of pharmacological effects will be also illustrated. Drug actions not mediated directly by receptors, the study of chemical structures of drugs and their actions on biological targets to alter cell function at molecular level, the Molecular Medicine of drug-receptor interactions and the technology for these studies will be also examined.

This course was specifically designed for Chemistry students; for details on arguments see previous section (Detailed Program).
Please contact the Professor for any instances or methodological questions you need.

R.F. Villa, A. Gorini, Principi di Farmacologia Generale, Casa Editrice Medea, Pavia.
A. Goodman-Gilman, Le Basi Farmacologiche della Terapia, Zanichelli, Bologna.

Oral Examination

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