ING-INF/06 (ELECTRONIC AND INFORMATION BIOENGINEERING)
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
2nd semester (01/03/2022 - 14/06/2022)
48 lesson hours
WRITTEN AND ORAL TEST
Basic knowledge of molecular biology, biochemistry and genetics is preferred.
Aims of the course are:
1. Get acquainted with several on-line bioinformatics tools;
2. Stimulate the students to a deeper and interdisciplinary knowledge of biological/biotechnological subjects by employing bioinformatics tools.
3. Gain a modern view of biology and biotechnology.
4. Learn data integration to gain insight into genotype-phenotype relationships of diseases;
5. Better understanding the relationships between life and environment (disease and pollution);
6. Plan new biotechnological tools (recombinant DNA, RNA or protein);
7. Gain insight into the interaction between small molecules and proteins.
8. Get an interdisciplinary integrated view of life science.
9. Gain basic knowledge of 'omics':
- Next Generation Sequencing
- RNA sequencing
- ChIP sequencing
- Drug discovery and reposinioning
- Cancer Imunotherapy
Main topics of the teaching are:
1 - The first session of the teaching describes and uses several bioinformatics tools and databases available on-line covering the following topics:
Genome browsers such as ENSEMBL, NCBI, UCSC; scientific literature; genomic data; genetic variant databases; gene expression databases; sequencing; databases on enzymatic, structural and functional features of proteins; protein complex databases; protein interaction databases; small molecules; pathways; sequence comparison and alignment; recombinant DNA software; genotype-phenotype relationships of human diseases.
2 - The second session of the teaching is dedicated towards the 'omics': Principle and application of the Next generation sequencing; Whole Exome sequencing, RNA-sequencing; ChIP sequencing; Microarray; Drug discovery and repositioning; Cancer immunotherapy and omics.
The teaching is also integrated with seminars on omics topics and also with hands-on sessions (Tutoring) in computerized classrooms.
Details are available for the students on the e-learning portal 'kiro'.
Academic lectures will be carried out mainly in classrooms equipped with wi-fi. Tutorials and hands-on sessions will be carried out in computerized classrooms by employing the UniPV e-learning platform (kiro): https://elearning2.unipv.it/bio/login/index.php
Reccomended or required readings
Several "HELP", "Tutorials" and "TRAINING" tools are available for each
bioinformatics tool described in the course.
More in detail: NCBI Training and Tutorials; NCBI Handbook, NCBI shelves; EBI
online; GenEnsembl help, documentations and tutorials; UCSC genome
Additional reports, documents and exercises will be provided during the course and
uploaded on e-learning platform, kiro, of the University of Pavia:
Written examination will assess the Students’ knowledge on the course topics. Assessment tests of about 20 questions in a form of: true/false; close, short, multiple or unique answers will be carried out on the e-learning platform, kiro: https://elearning2.unipv.it/bio/login/index.php
please e-mail your requests to the university e-mail address only, messages sent to private or job e-mail addresses will be not considered
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