2020/2021

2021/2022

DM270

MED/26 (NEUROLOGY)

DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"

NEUROBIOLOGY

PERCORSO COMUNE

2°

(01/10/2021 - 14/01/2022)

6

48 lesson hours

Italian

ORAL TEST

BLANDINI FABIO - 3 ECTS
CORTESE ANDREA - 3 ECTS

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Module 2. The first part of the course is a monographic course of prion diseases. It traces the history of the discovery of human spongiform encephalopathies and their systematization on the basis of clinical and pathologic findings. Then we introduce the discovery of Kuru and its infectious nature by the Nobel Prize C Gadjusek. It is retraced the long journey of discovery of the infectious agent of scrapie, Kuru and of human spongiform encephalopathies. The discovery of the prion protein and its characterization is described together with the epidemic of bovine prion disease in England and the variant-CJD linked to it. A discussion of the mechanisms of neurodegeneration follows. Multiple Sclerosis, its pathological anatomy, pathophysiology is faced. Brain tumors are treated from the standpoint of clinical, pathophysiological and pathological. Vision is treated starting from the physics of light and visual recognition of beauty. It is hinted at the approach to the problem of consciousness in neuroscience.
Module 3. Clinical and epidemiological aspects of Parkinson’s disease and Alzheimer’s disease. Neuroanatomical description of the neural systems involved in these diseases. Pathogenic hypotheses. Pathophysiology. Evaluation of available experimental models (toxic and transgenic). Current treatments and future therapeutic perspectives.

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Vengono fornite allo studente le diapositive e indicazioni di lavori scientifici inerenti agli argomenti trattati

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