ADVANCED SYSTEMIC NEUROPHISILOGY
Stampa
Enrollment year
2020/2021
Academic year
2021/2022
Regulations
DM270
Academic discipline
BIO/09 (PHYSIOLOGY)
Department
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
Course
NEUROBIOLOGY
Curriculum
PERCORSO COMUNE
Year of study
Period
1st semester (01/10/2021 - 14/01/2022)
ECTS
9
Lesson hours
72 lesson hours
Language
Italian
Activity type
WRITTEN TEST
Teacher
D'ANGELO EGIDIO UGO (titolare) - 6 ECTS
PALESI FULVIA - 3 ECTS
Prerequisites
Neuroanatomy and neurophysiology basis
Learning outcomes
Know and understand the neural basis of cognitive processes, the basis of computation modeling of single neurons, microcircuits and neural networks.
Course contents
Brain functional architecture
- Structure, function, dynamics and control
- Computation, coding, information
- Interaction between sensorimotor and cognitive sub-systems
- Closed-loop computation
o Forward and inverse controllers
o Error detection
- Circuit mechanisms of learning and memory
- Circuit mechanisms of computation and information transfer
Multiscale organization of the nervous system
- Microscale: molecular and cellular aspects, neurons and microcircuits
- Mesoscale: multineuronal assemblies
- Macroscale: large scale networks
Instrumental analysis of integrated functions
- Techniques for the measurement of ensemble neuronal functions
- Analysis of distributed signals
- CT, PET
- TMS, EEG, MEG
- MRI (basis, diffusion and functional)
- Brain Atlases
- Connectomics
- The inverse problem: inferring source activity from ensemble signals

Multiscale modelling of nervous functions
- Principles of realistic brain modelling
o Single neuron models (Hodgkin-Huxley style)
o Microcircuit models
- Model simplification and large-scale models
- SNN theory
- Brain modelling
o Bayesian inference and model inversion
o The Virtual Brain
o Dynamics causal modelling

Applications
- Neurophysiology and neuropathology
- Neuroinformatics
- Neurobotics
- Neuromorphic computing
Teaching methods
Face-to-face lectures or by videoconference according to the regulations in force of covid pandemic situation. Possible seminars to expand the student knowledge.
Reccomended or required readings
D’Angelo-Peres FISIOLOGIA – Edi-ermes
Assessment methods
Oral exam: learning is verified by oral examination
aimed at ascertaining the achievement of the educational objectives of the teaching.
The subject of the exam is the contents of the lectures and educational seminars.
Further information
Sustainable development goals - Agenda 2030