DEVELOPMENTAL AND STEM CELL BIOLOGY
Stampa
Enrollment year
2020/2021
Academic year
2021/2022
Regulations
DM270
Academic discipline
BIO/06 (COMPARATIVE ANATOMY AND CYTOLOGY)
Department
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
Course
EXPERIMENTAL AND APPLIED BIOLOGY
Curriculum
Scienze biomediche molecolari
Year of study
Period
1st semester (01/10/2021 - 14/01/2022)
ECTS
6
Lesson hours
48 lesson hours
Language
Italian
Activity type
ORAL TEST
Teacher
GARAGNA SILVIA (titolare) - 6 ECTS
Prerequisites
Good knowledge of cell and molecular biology, genetics.
Learning outcomes
The course aims at providing students with basic knowledge of the cellular and molecular mechanisms of development. Also, the course aims at providing basic knowledge on the properties and functional plasticity of stem cells.
At the end of the course the student will acquire specific and critical knowledge oo:
1. the modalities of development and differentiation of the male and female gonads and gametes;
2. the mechanisms of fertilization and peri-implantation embryonic development;
3. the derivation of stem cells from mammalian embryos;
4. the cellular and molecular characteristics of the different types of stem cells;
5. the localization and tissue regulation of stem cells.
Course contents
DEVELOPMENTAL BIOLOGY
Mechanisms of sex determination. Gonad differentiation and sexual differentiation. Germ cell development. Spermatogenesis and oogenesis. Fertilisation. Segmentation. Embryonic genome activation. Imprinting. Genome equivalence. Cloning. Origin and specification of embryonic germ layers. Gastrulation.

BIOLOGY OF STEM CELLS
Sources and molecular characteristics of stem cells. Origin of embryonic stem cells and their derivation methods. The pluripotency molecular core and its regulation. Differentiation of embryonic stem cells. Cell reprogramming and the induction of pluripotency. Characteristic and function of spermatogonia in the mammalian testis. Role of stem cells in adult tissues. The stem cell niche.
Teaching methods
The course is carried out through lectures using Power Point presentations. Lessons will available to students as pdf files

The course can possibly be supplemented by in-depth seminars.





No educational or tutored seminars are planned.
Reccomended or required readings
Giudice et al. Biologia dello Sviluppo, Piccin Editore, 2010, or other books of Developmental Biology. Slides of the lessons will be given.
Assessment methods
The exam is written and is composed of two questions: one for the development biology module and one for the stem cell biology module to be answered in full.
The duration of the test is 1 hour and the evaluation is out of thirty.
Further information
The teacher is available for clarification on the contents of the lessons following appointment.
Sustainable development goals - Agenda 2030
Goal 4. High quality ducation
The goals