Enrollment year
2020/2021
Academic discipline
MED/04 (GENERAL PATHOLOGY)
Department
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
Course
EXPERIMENTAL AND APPLIED BIOLOGY
Curriculum
Scienze biomediche molecolari
Period
2nd semester (01/03/2021 - 14/06/2021)
Lesson hours
48 lesson hours
Activity type
WRITTEN AND ORAL TEST
Prerequisites
The contents of the course of General Pathology, in particular cellular pathology, inflammation and tumour.
Learning outcomes
The objective of the course is to introduce students to molecular alterations involved in cancer and their application in the prevention, diagnosis and prognosis of cancer with the aim to prepare the student to the research in medical field.
Part 2: we will focus on the molecular bases of HLA-associated diseases. We emphasize the role of HLA and KIR gene epistatic interaction in adaptive and innate immune response. The immunogenetic aspect of population studies, pregnancy and transplant will be presented.
Course contents
Part 1. The aim of the course is to introduce students to the molecular alterations that are used in diagnosis and prognosis of cancer. Considering the biology of cancer, biomarkers of transformation, invasivity and metastases will be evaluated. Moreover viral, bacterial and tumor microenvironment biomarkers will be also examined. Biomarkers used in molecular epidemiology such as DNA adducts, genetic, chromosomal alteration and susceptibility markers will be also evaluated. Finally, different therapeutic strategies will be described.
Part 2. The aim of the second part is to deepen the knowledge on HLA and KIR genetic systems (genes proteins and functions). In particular we will focus on the HLA and KIR polygenic systems; multiallelic genes; codominance; ancestral haplotypes; linkage disequilibrium; HLA genes of class3 : complement genes, CYP-21 and HSP-70 genes and proteins, TNF locus; donor-recipient histocompatibility and transplant: role of major (HLA) and minor antigens, role of KIR genes; susceptibility/protection genes in immune and autoimmune diseases (study of families and population).
Teaching methods
=Lectures
Reccomended or required readings
Pontieri. Patologia Generale e Fisiopatologia Generale. Tomo I.
PICCIN.
Robbins e Cotran Pathological Bases of Diseases.
Elsevier
Papers concerning subjects discussed during the lectures will be suggested.
Assessment methods
Written and/or oral exam
Further information
Written and/or oral exam
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa