2019/2020

2020/2021

DM270

CHIM/11 (CHEMISTRY AND BIOTECHNOLOGY OF FERMENTATIONS)

DEPARTMENT OF MOLECULAR MEDICINE

MEDICAL AND PHARMACEUTICAL TECHNOLOGIES

Farmaceutico:Biotecnologie farmaceutiche per la ricerca e sviluppo

2°

(05/10/2020 - 22/01/2021)

3

24 lesson hours

Italian

WRITTEN TEST

UBIALI DANIELA - 3 ECTS

To attend this course, a good knowledge of organic chemistry as well as microbiology (in particular the metabolism of microrganisms) is required

This course aims at providing students with the knowledge about discovery, classification, biosynthesis, mechanism of action, and structure-activity relationships (SAR study) of the more relevant classes of antibiotics produced by fermentation

-Introduction to fermentation antibiotics
-Genetics of producer microrganisms and methods of strain improvement (basics)
-Beta-lactam antibiotics
-Glycopeptide antibiotics
-Macrolides and tetracyclines
-Aminoglycosides and rifamycin
-The downstream process in industrial fermentations

Lectures supported by slides and videos. Seminars will be also given by experts in industrial fermentation both from University and industry
In compliance with the regulations concerning physical distancing for the control of COVID-19 pandemic, lectures will be given in the classroom to small groups on a weekly rotation basis (see https://web.unipv.it/coronavirus/ for more details). All lectures will be also available online (Kiro).
Depending on the number of students and the evolution of the sanitary situation (COVID-19), a visit to fermentation industrial plants might be scheduled

Slides and scientific papers provided by the professor.
Reference books:
B.R. Glock and J.J. Pasternak, Biotecnologia molecolare, Zanichelli
G.Lancini and R. Lorenzetti, Biotechnology of antibiotics and other bioactive microbial metabolites, Plenum Press
F. Marinelli and O. Genilloud, Antimicrobials: new and old molecules in the fight against multi-resistant bacteria, Springer
A. Moreira, Volume 3 Industrial biotechnology and commodity products, Comprehensive Biotechnology, second edition, Elsevier

Students will be examined by an oral exam aimed at verifying the achievement of the educational goals laid out (see “Obiettivi formativi”).
Correctness of contents, completeness of answers, property of language, and knowledge of technical terminology will be assessed.
The exam will be passed if students achieve a grade in the 18-30 cum laude range.

Slides used during lectures can be downloaded from the website Kiro. Videos and scientific papers (both in English) are also available in Kiro. Communications/notices to the students will be uploaded in Kiro, too.