Enrollment year
2019/2020
Academic discipline
BIO/11 (MOLECULAR BIOLOGY)
Department
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
Curriculum
PERCORSO COMUNE
Period
2nd semester (01/03/2020 - 14/06/2020)
Lesson hours
48 lesson hours
Prerequisites
Bachelor-level knowledge of molecular biology, chemistry and math.
Learning outcomes
This course investigates the fundamental concepts and methods for the study of the structures of biological macromolecules with a focus on the implications for drug development and design.
Course contents
Methods for the study of the three-dimensional structure of biological macromolecules.
Introduction to biocrystallography.
Diffraction theory.
The phase problem and methods for its solution.
Experimental methods in biocrystallography.
NMR spectroscopy
Single particle EM
3D image reconstruction
Structure-based drug design
Examples of the application of the structural biology methods for drug development
Teaching methods
Lectures
Reccomended or required readings
Physical Biochemistry: Principles and Applications, 2nd Edition
David Sheehan
Wiley-Blackwell
Assessment methods
Oral test
Further information
Oral test
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa