2019/2020

2020/2021

DM270

CHIM/02 (PHYSICAL CHEMISTRY)

DEPARTMENT OF DRUGS SCIENCES

MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY

PERCORSO COMUNE

2°

1st semester (12/10/2020 - 29/01/2021)

9

72 lesson hours

Italian

WRITTEN TEST

MILANESE CHIARA (titolare) - 9 ECTS

Needed concepts:
Inorganic chemistry (mole, molar mass, concentration of a solution, molarity, molality, calculation of the numbers of moles for a component in solution or in a gaseous mixture, molar fraction);
Analytical geometry (equation of a straight line, of a parable and an hyperbole);
Maths (exponential and logarithmic function, first derivative of a function, integrals).

The course aims to give to the students the scientific and methodological knowledge needed to understand and to
deepen the physical-chemistry of biological, pharmaceutical and pharmacological processes. The course will deal with
the thermodynamic topics useful to understand and to manage phase equilibriums, transport processes and separation
processes. Attention will be also devoted to the kinetics of chemical and physico-chemical processes in order to make the
students able to approach from a rational point of view any biological, pharmaceutical and pharmacological issue. The discussion of the theoretical principles will be supported and integrated by the analysis of the experimental aspects,
combining the scientific knowledge and the ability to do. To this aim, some of the most important experimental
techniques in the biological and pharmaceutical fields will be discussed.

Mathematical reminding, general aspects of Physical Chemistry and of its applications to Biology and Pharmaceutics. First thermodynamic principle and enthalpy. Enthalpy changes of physical, chemical and biological transformations. Second thermodynamic principle: entropy, its statistical meaning and its importance in biological processes. Gibbs energy; spontaneity of physical, chemical and biological processes; the work function. Phase equilibria, phase diagrams and phase transitions. Kinetics; reaction rate and reaction mechanisms. Physico-chemical experimental techniques in biochemistry and pharmaceutics.

The course is based on theoretical lectures given by the teacher using slides in ppt or pdf format and suitable media to help describing and understanding the phenomena and the physical processes. Numerical exercises related to the theoretical subjects explained in the lectures will be done by the teachers in the class at the blackboard, in order to help the students to follow each single step of the resolution and to discuss together the formula and the equations to be used and their practical meaning. Great attention is devoted to the physical meaning of each parameter and to the correct use of the related measurement units. To further help the students, some more numerical exercises by the tutors of the course will be planned in agreement with the students and their availability.

The needed concepts are all present in the slides projected by the teacher and in the lectures notes provided and upload in the Kiro repository. Moreover, the reading of a physical chemistry text book suitable for university students in scientific disciplines is advised. Some examples are reported in the following lines (available also in English):
P. Atkins, J. De Palma "Chimica Fisica Biologica", Zanichelli;
P. Atkins, J. De Palma " Elementi di Chimica Fisica", Zanichelli;
R Chang "Chimica Fisica", Zanichelli.

The learning steps of the students will be verified by frequent discussions and questions during the lectures and a continuos interaction among the teacher and the students. Problems and exercises will be performed by the teacher during the lectures with the collaboration of the students.

Conditions to pass the exam: the exam can be passed by passing the final written exam in the official dates. The exam is constituted by 5 open questions and 5 numerical exercises and is focused on the whole program of the course.

The learning steps of the students will be verified by frequent discussions and questions during the lectures and a continuos interaction among the teacher and the students. Problems and exercises will be performed by the teacher during the lectures with the collaboration of the students.

Conditions to pass the exam: the exam can be passed by passing the final written exam in the official dates. The exam is constituted by 5 open questions and 5 numerical exercises and is focused on the whole program of the course.