2017/2018

2019/2020

DM270

CHIM/03 (GENERAL AND INORGANIC CHEMISTRY)

DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"

BIOTECHNOLOGY

PERCORSO COMUNE

3°

2nd semester (01/03/2020 - 14/06/2020)

6

48 lesson hours

Italian

ORAL TEST

NICOLIS STEFANIA (titolare) - 6 ECTS

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The course aims to study the role of metals in biological systems. In particular, starting from the deepening of topics of inorganic chemistry partially introduced in previous courses, with particular regard to the chemistry of metal compounds, students are given the tools to understand the interaction of metal ions with biological macromolecules and the mechanisms of action of some classes of metal proteins and metal enzymes of greatest biological interest.

The topics covered in the course are as follows: electrons, elements of quantum mechanics; atoms, atomic orbitals and periodic properties; molecules, chemical bond and molecular orbitals; chemistry of coordination compounds: stability, isomerism, ligand field stabilization energy, magnetic properties, kinetics and reaction mechanisms; binding of oxygen and other small molecules to metals; interaction of metal ions with nucleic bases/nucleotides/DNA, antitumor activity of platinum compounds; proteins: structure and function; electron spectroscopy and natural chromophores, complexes with macrocyclic ligands (vitamin B12, chlorophyll, heme group); oxidative stress for metal-biomolecule interactions; metalloproteins and metalloenzymes, classification and functions; electron transport proteins; oxygen transport proteins; enzymes containing heme iron, not-heme iron and copper centers.

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