Enrollment year
2017/2018
Academic discipline
BIO/14 (PHARMACOLOGY)
Department
DEPARTMENT OF DRUGS SCIENCES
Course
MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY
Curriculum
PERCORSO COMUNE
Period
(01/10/2019 - 31/01/2020)
Lesson hours
48 lesson hours
Activity type
WRITTEN TEST
Learning outcomes
The basic toxicology subjects will be approached; in vitro and in vivo tests will be described in the light of EU laws and
the REACH guidelines.
Course contents
The course is divided into three sections. The first section deals with biotransformation reactions, identification of
potentially toxic molecules and reactive groups, study of the enzymes involved in biotransformation. Apoptosis,
mutagenesis, cancerogenesis and teratogenesis related to toxic exposure are also illustrated, together with the relative
in vitro and in vivo tests.
The second section deals with target organ toxicology: potential toxic effects of substances on organ functions will be
illustrated, with relation to epidemiological data or general acute or chronic toxicity studies. A special section deals with obligatory vaccines in Italy (Legge 31 luglio 2017, n. 119).
The third section deals with toxicity profiles of different molecule families such as drugs of abuse, pesticides,
environmental contaminants. Food related toxicity and contamination is also illustrated.
Reccomended or required readings
Balduini, Costa, Manzo, Paolillo, Vitalone. "Tossicologia generale e applicata ai farmaci",Prima Edizione, casa editrice Edra Masson
Assessment methods
No practical exams.
No in itinere tests. A final exam at the end of the course. Students not familiar with Italian language can ask for an oral
test.
Further information
No practical exams.
No in itinere tests. A final exam at the end of the course. Students not familiar with Italian language can ask for an oral
test.
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa