DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY "LAZZARO SPALLANZANI"
2nd semester (01/03/2019 - 14/06/2019)
48 lesson hours
Detailed knowledge of structural and metabolic biochemistry as learned from the course at the II year.
Coordinated regulation of metabolism. Integration of metabolic pathways. Metabolic profiles of liver, muscle, adipose tissue, brain. Metabolic adaption under short and prolonged starvation. Diabetes. Metabolism of ethanol.
Drug metabolism. Role of liver in the metabolism of xenobiotics. The cytochrome P450 oxidases. Xenobiotic conjugation. Glutathione. Bilirubin metabolism.
Sorting and targeting of proteins. Protein targeting to the nucleus, mitochondria, and peroxisomes. The secretory pathway. Protein glycosylation: O-linked and N-linked oligosaccharides. Role of mannose-6-phosphate in lisosomal targeting of proteins. Intracellular traffic of vesicles: clatrin, COPI and COPII. Receptor-mediated endocytosis.
Blood biochemistry. Cholesterol and bile acids. Lipoproteins. Atherosclerosis. Hemostasis and thrombosis: coagulation, fibrinolysis, role of platelets and endothelial cells. Inflammation: macrophages and neutrophils function.
Hormones biochemistry. Thyroid hormones. Steroid hormones. Hormones in calcium homeostasis. Biosynthesis, secretion, transport. Hormone signaling: receptors, intracellular effectors, second messengers. Protein phosphorylation in signaling cascades.
Reccomended or required readings
Nelson DL, COX, MM : I Principi di Biochimica di Lehninger, Zanichelli;
Berg JM, Tymoczko JL, Stryer L: Biochimica, Zanichelli;
Campbell, Farrell: Biochimica, Edises,
Alberts et al: Biologia Molecolare della Cellula, Zanichelli
Murray et al: Harper Biochimica, McGraw
Sustainable development goals - Agenda 2030