2015/2016

2018/2019

DM270

CHIM/08 (PHARMACEUTICAL CHEMISTRY)

DEPARTMENT OF DRUGS SCIENCES

MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY

PERCORSO COMUNE

4°

(04/03/2019 - 19/06/2019)

6

56 lesson hours

ORAL TEST

DE LORENZI ERSILIA (titolare) - 6 ECTS

To attend this course knowledge of inorganic and organic chemistry, medicinal chemistry, spectroscopy and chromatography is requested.

At the end of the course the student will be trained on theoretical, applicative and practical aspects of the instrumental techniques and methodologies commonly used in the pharmaceutical industry for the analysis of actives in pharmaceutical dosage forms and biological matrices. The complementary aspects will favour the student capabilities in setting up an analytical method.

Sample preparation (LLE, SPE); stationary phases for LC (theory and applications); validation of analytical methods according to ICH Guidelines; chiral LC stationary phases (theory and applications); supercritical fluid chromatography and supercritical fluid extraction (theory and applications); capillary electrophoresis, CE (theory and applications); UPLC (theory and applications); micro e nano HPLC (theory and applications). Reading and discussion of peer-reviewed scientific papers selected by the lecturer and related to some of the topics above mentioned.

The course is organised in three complementary sections: 1. Lectures on theoretical basis of instrumental techniques for pharmaceutical analysis; 2. Searching, reading and discussion of peer-reviewed scientific papers related to applications of the instrumental techniques; 3. Practicals: HPLC (qualitative and quantitative analysis of an active substance of pharmaceutical interest). CE (qualitative and quantitative analysis of an active substance of pharmaceutical interest).

Cavrini V., Andrisano V., PRINCIPI DI ANALISI FARMACEUTICA 3a ed., Esculapio; Skoog, Holler, Nieman, PRINCIPLES OF INSTRUMENTAL ANALYSIS, Harcourt Brace; Saini G., Mentasti E, FONDAMENTI DI CHIMICA ANALITICA (analisi chimica strumentale), UTET; Snyder L.R., PRACTICAL HPLC METHOD DEVELOPMENT, Wiley; Ahuja, S. Jimidar MI, CAPILLARY ELECTROPHORESIS METHODS FOR PHARMACEUTICAL ANALYSIS, Academic Press;Pawliszyn J., Lord H.L., HANDBOOK OF SAMPLE PREPARATION, Wiley;

Two midterm tests are envisaged, one at early stages of the course (to verify knowledge of prerequisites) and one before the end of the semester. They are open to all students upon registration, they are not assessed and are intended to be used by the student for a self-test of his/her level of comprehension/preparation.
The final exam is oral, to better evaluate whether the student is able to critically integrate and discuss the theoretical, applicative and practical aspects of the use of instrumental techniques for pharmaceutical analysis.

Two midterm tests are envisaged, one at early stages of the course (to verify knowledge of prerequisites) and one before the end of the semester. They are open to all students upon registration, they are not assessed and are intended to be used by the student for a self-test of his/her level of comprehension/preparation.
The final exam is oral, to better evaluate whether the student is able to critically integrate and discuss the theoretical, applicative and practical aspects of the use of instrumental techniques for pharmaceutical analysis.