2014/2015

2017/2018

DM270

CHIM/08 (PHARMACEUTICAL CHEMISTRY)

DEPARTMENT OF DRUGS SCIENCES

MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY

PERCORSO COMUNE

4°

(01/03/2018 - 19/06/2018)

6

68 lesson hours

Italian

WRITTEN TEST

UBIALI DANIELA - 6 ECTS

To attend this course, knowledge of inorganic chemistry, organic chemistry and medicinal chemistry is required.

Learning the basic techniques of practical organic chemistry for the obtainment of biologically active molecules of pharmaceutical interest.
Learning the tools to carry out a literature search aimed at designing a chemical synthesis.
Learning the main safety standards to be adopted in chemical laboratories for the prevention of accidents.

Contents: lectures (3,5 CFU, 28 hours) and laboratory training (2,5 CFU, 40 hours), strictly interconnected.
Laboratory training: students will directly experiment the basic methods and techniques routinely used to synthesize active pharmaceutical ingredients (APIs) and to isolate bioactive compounds from vegetable sources.
Programme: synthesis of known small molecules (also by biocatalysis), use of separative techniques (liquid-liquid extraction, crystallization, distillation, chromatography, evaporation, filtration), use of equipments routinely found in organic chemistry laboratories.
Students are expected to work in groups (no more than 5 students/group). Students are required to register daily the experimental activities in a personal lab notebook according to the guidelines provided during the course.

Lectures and lab training. One lecture (seminar) will be given by a researcher from pharmaceutical industry.

AA.VV. “Vogel, chimica organica pratica” Casa Editrice Ambrosiana Milano
D. L. Pavia, G. M. Lampman, G. S. Kriz “Il laboratorio di chimica organica” Edizioni Sorbona Milano
K. Faber “Biotransformations in Organic Chemistry – A textbook” Springer Ed.

One midterm exam is scheduled at the end of the course (lectures and laboratory training).

Final exam: 1) first option: passing the midterm exam and the laboratory training;
2) second option: if a student has not taken the midterm exam or has failed it, he/she must take the whole exam (Chimica e Analisi Farmaceutica 3, 12 CFU) on scheduled exam sessions. Also in this case, a positive evaluation in the laboratory training is mandatory to be admitted to the final exam.

Slides used during lectures can be downloaded from the website Kiro. Tutorial videos about the main techniques of organic synthesis and scientific papers (both in English) are also available in Kiro. Registration to the laboratory training is mandatory and must be done by signing up the form in Kiro by the reported deadline. Communications/notices to the students will be uploaded in Kiro, too.