2019/2020

2020/2021

DM270

BIO/09 (FISIOLOGIA)

DIPARTIMENTO DI MEDICINA MOLECOLARE

MEDICINA E CHIRURGIA (IN LINGUA INGLESE)

PERCORSO COMUNE

2°

Primo Semestre (01/10/2020 - 15/01/2021)

3

24 ore di attività frontale

English

SCRITTO E ORALE CONGIUNTI

BOTTINELLI ROBERTO (titolare) - 3 CFU

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The course will teach students the phenomena occurring at molecular, cellular, tissue and organ level which support vital functions. At the end of the course, students will know how the organs and systems of the human body work, how their cooperate, and how their function is controlled to keep homeostasis. What is taught at all level of organisation of the living matter will be put in the frame of the way the organism works. Students will learn the major correlations between the phenomena occurring in physiologic and pathologic conditions.

System Overview
Pressure, Flow, and Resistance
The Heart
Anatomy
Cardiac Muscle
Heartbeat Coordination
Sequence of Excitation
Cardiac Action Potentials and Excitation of the SA Node
The Electrocardiogram
Excitation–Contraction Coupling
Refractory Period of the Heart
Mechanical Events of the Cardiac Cycle
Mid-Diastole to Late Diastole
Systole
Early Diastole
Pulmonary Circulation Pressures
Heart Sounds
The Cardiac Output
Control of Heart Rate
Control of Stroke Volume
Measurement of Cardiac Function
The Vascular System
Arteries
Arterial Blood Pressure
Measurement of Systemic Arterial Pressure
Arterioles
Local Controls
Extrinsic Controls
Endothelial Cells and Vascular Smooth Muscle
Arteriolar Control in Specific Organs
Capillaries
Anatomy of the Capillary Network
Velocity of Capillary Blood Flow
Diffusion Across the Capillary Wall: Exchanges of Nutrients and Metabolic End Products
Bulk Flow Across the Capillary Wall: Distribution of the Extracellular Fluid
Veins
Determinants of Venous Pressure
The Lymphatic System
Mechanism of Lymph Flow
Integration of Cardiovascular Function: Regulation of Systemic Arterial Pressure
Baroreceptor Reflexes
Arterial Baroreceptors
The Medullary Cardiovascular Center
Operation of the Arterial Baroreceptor Reflex
Other Baroreceptors
Blood Volume and Long-Term Regulation of Arterial Pressure
Other Cardiovascular Reflexes and Responses
Cardiovascular Patterns in Health and Disease
Hemorrhage and Other Causes of Hypotension
Shock
The Upright Posture
Exercise
Maximal Oxygen Consumption and Training
Hypertension
Heart Failure
Hypertrophic Cardiomyopathy
Coronary Artery Disease and Heart Attacks
Blood and Hemostasis
Plasma
The Blood Cells
Erythrocytes
Leukocytes
Platelets
Regulation of Blood Cell Production
Hemostasis: The Prevention of Blood Loss
Formation of a Platelet Plug
Blood Coagulation: Clot Formation
Anticlotting Systems
Anticlotting Drugs

Lectures, rehearsal and questions and answers to the class

One of the following books:

Vander's Human Physiology, 14th Edition - McGraw Hill

Ganong's Review of Medical Physiology, 25th Edition - McGraw Hill

Berne & Levy Physiology, 6th Edition - Elsevier

written test (multiple choices) & oral exam

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