2019/2020

2020/2021

DM270

BIO/09 (FISIOLOGIA)

DIPARTIMENTO DI MEDICINA MOLECOLARE

MEDICINA E CHIRURGIA (IN LINGUA INGLESE)

PERCORSO COMUNE

2°

Primo Semestre (01/10/2020 - 15/01/2021)

3

24 ore di attività frontale

English

SCRITTO E ORALE CONGIUNTI

LEFKIMMIATIS KONSTANTINOS - 3 CFU

-

The course will teach students the phenomena occurring at molecular, cellular, tissue and organ level which support vital functions. At the end of the course, students will know how the organs and systems of the human body work, how their cooperate, and how their function is controlled to keep homeostasis. What is taught at all level of organisation of the living matter will be pout in the frame of the way the organism works. Students will learn the major correlations between the phenomena occurring in physiologic and pathologic conditions.

Cell and body fluid compartments
Levels of cellular organization
Cell types, tissue and organs
Extracellular matrix
Internal environment and body water
Homeostasis
Feed-back systems
Resetting of set points
Feedforward regulation
Regulation of body temperature
Reflexes
Local homeostatic responses
Adaptation and acclimatization
Biological rhythms
Balance of chemical substances in the body
Intercellular communications
Main methods of cell to cell communication
Signals and receptors
Hydrophobic and hydrophilic signals and receptors
Intracellular pathways initiated by lipid-soluble messengers
Intracellular pathways initiated by water-soluble messengers
Plasma membrane receptors and gene transcription
Modulation of intracellular pathways
Inactivation of intracellular pathways
Excitable tissues
Neurons and cells of the nervous system
Organization of the nervous system: general concepts
Morphology
Cytoskeleton & axon transport
Glial cells and myelinated and un-myelinated axons
Electrical phenomena in neurons
Resting membrane potential
Graded potentials
Action potentials
Action potential conduction
Synapses
Functional Anatomy of Synapses
Mechanisms of Neurotransmitter Release
Activation of the Postsynaptic Cell
Excitatory Chemical Synapses
Inhibitory Chemical Synapses
Synaptic Integration
Synaptic Strength
Modification of Synaptic Transmission by Drugs and Disease
Neurotransmitters and Neuromodulators
Acetylcholine
Biogenic Amines
Amino Acid Neurotransmitters
Neuropeptides
Gases
Purines
Cardiac Muscle
Cellular Structure of Cardiac Muscle
Excitation–Contraction Coupling in Cardiac Muscle
Regulation of force
Action potential

Lectures, rehearsal and questions and answers to the class

One of the following books

Vander's Human Physiology, 14th Edition - McGraw Hill

Ganong's Review of Medical Physiology, 25th Edition - McGraw Hill

Berne & Levy Physiology, 6th Edition - Elsevier

written text (multiple choices) & oral exam

-