2019/2020

2019/2020

DM270

BIO/10 (BIOCHIMICA)

DIPARTIMENTO DI MEDICINA MOLECOLARE

MEDICINA E CHIRURGIA (IN LINGUA INGLESE)

PERCORSO COMUNE

1°

Primo Semestre (01/10/2019 - 17/01/2020)

7

56 ore di attività frontale

SCRITTO

FORLINO ANTONELLA - 1 CFU
ROSSI ANTONIO - 6 CFU

In-depth knowledge of chemistry are preparatory to Biochemistry Course

In the Biochemistry, Cellular Biochemistry and Molecular Biology modules the structure-function relationships of biological molecules, signalling pathways and metabolism are illustrated.
Through the knowledge of how molecules and cells work, the chemical processes that define them, and how they interact with one another, students will get an in-depth insight into how cells and tissues function in health and sickness and how we can use that knowledge to understand the basis of treatments for diseases. Thus, the course is crucial and will pave the way for a molecular approach to physiology, pathology and pharmacology courses.

Biochemistry module
Following the structure and properties of amino acids, the structure and function of proteins are considered with reference to the main protein classes; then, fundamentals of catalysis and enzyme properties and mechanisms are discussed. The structure and properties of carbohydrates and lipids, including glycoproteins, glycolipids and glycosaminoglycans are presented. The structure and function of nucleic acids terminate the structural part of the course.
Metabolism is introduced by a discussion of the principles governing metabolism including bioenergetics, compartmentalization, and the operation and control of pathways. Major metabolic pathways of carbohydrate metabolism are discussed. This is followed by oxidative metabolism and lipid metabolism (i.e., triglycerides, phospholipids and sterols). Then, the metabolism of amino acids, porphyrins and nucleotides are developed. Finally the synthesis of ATP by oxidative phosphorylation is considered. After taking into account the distinct metabolic pathways, their integration, hormonal regulation and tissue-specific metabolism are described.

Lectures using Power-Point presentations.

D. Nelson, M. Cox
Lehninger PRINCIPLES OF BIOCHEMISTRY. 5th or 6th edition.
ISBN-10: 1464109621; ISBN-13: 978-1464109621

J. Berg, J. Tymoczko, L. Stryer
BIOCHEMISTRY 7th edition.
ISBN-10: 071676766X; ISBN-13: 978-0716767664

The exam is written on the topics covered in the lectures of the Biochemistry, Cellular Biochemistry and Molecular Biology modules.