2017/2018

2019/2020

DM270

BIO/14 (FARMACOLOGIA)

DIPARTIMENTO DI MEDICINA MOLECOLARE

MEDICINA E CHIRURGIA (IN LINGUA INGLESE)

PERCORSO COMUNE

3°

Primo Semestre (01/10/2019 - 17/01/2020)

1

8 ore di attività frontale

English

SCRITTO

FERRIGNO ANDREA (titolare) - 1 CFU

Notions of General Pharmacology will help the student to undestand the lessons. In particular, will be useful some general concepts of pharmacokinetics, such as:
- drug absorption, concentration/time slope after oral or intravenous administration, maximum plasmatic concentration, elimination half time
- drug distribution, apparent volume of distribution, plasmatic distribution, extracellular distribution, intracellular distribution
- drug elimination: renal excretion, hepatic metabolization, hepatic cytochromes.
Basic notions of microbiology will be useful too:
- Gram-positive and Gram-negative bacteria
- DNA and RNA viruses

The students will aquire the classification, pharmacokinetics, pharmacodinamics and side effects of antibacterial, antiviral and anticancer drugs.
Furthermore, the students will have to demonstrate to have aquired the concept of reasonable use of antibiotic and antiviral drugs, in order to preserve the efficaci of chemotherapics and minimize the spread of bacterial and viral resistance.
Notions about the therapeutic use of the studied drugs, according to the most updated guidelines, will be requested too.

Part I and II: Antibacterial drugs
- International guidelines for the therapy of meningitis, pneumonia, endocarditis and Group B streptococci faringitis.
- Betalactams (penicillins, cephalosporins, carbapenems, monobactams)
- aminoglycosides
- macrolides
- vancomycin
- linezolid
- daptomycin
Part III: antiviral drugs
- International guidelines for the treatment of viral influenza
- International guidelines for the treatment of Hepatitis C
- antiherpes (aciclovir)
- antiflu (amantadin, rimantatin, oseltamivir, zanamifir)
- anti HBV, anti HCV

Part IV: anticancer drugs
cytotoxic drugs:
- alkilating agents
- antimetabolites
- antimitotic from plants
- cytotoxic antibiotics
- kinase inhibitors
- monoclonal antibodies

Traditional teacher up-front classes and exercise sessions will be held. Examples of the exam tests will be showed.

Goodman & Gilman's Pharmacologic basis of Therapeutics
Rang's Pharmacology

Multiple choice test. Students will be given 30 minutes to answer to 25 multichoice questions. The questions are strictly taken from the slides showed during the lessons.

To request a meeting, write to andrea.ferrigno@unipv.it or phone to 0382.98.64.51