Enrollment year
2021/2022
Academic discipline
MED/08 (PATHOLOGICAL ANATOMY)
Department
DEPARTMENT OF MOLECULAR MEDICINE
Course
MEDICAL AND PHARMACEUTICAL TECHNOLOGIES
Curriculum
Medico: Biotecnologie mediche e ricerca biomedica
Period
1st semester (03/10/2022 - 20/01/2023)
Lesson hours
48 lesson hours
Prerequisites
Human anatomy, human histology, genetic, general pathology, phisiology
Learning outcomes
At the end of the course the students will be able to understand the role of the pathological anatomy and of the ancillary techniques in the diagnosis and treatment of the main diseases and they will be able to recognise the histopathological changes related to these conditions.
They will also learn the molecular bases of the oncogenetic mechanisms, the main analysis techniques, and the diagnostic, prognostic and predictive role of the molecular study in oncology. Lastly, they will learn the principles of electronic microscopy and some of its diagnostic applications.
Course contents
Pathological anatomy. General aspects.
Pathological anatomy. Main organs and systems.
Ancillary techniques in pathological anatomy.
Management of biopsy samples and bio – banking
Immunohistochemistry and principal fields of applications
FISH technique
Clonality analysis in lymphoproliferative disease
Basic technique: nucleic acid extraction and microdissection
Molecular oncogenesis principles: cancer as a genetic disease; oncogenes and oncosuppressor genes
Genomic instability, LOH, SNIPs, traslocations, amplifications: significance and analysis techniques
Metilation, micro RNA, clonality: significance and analysis techniques
Gene expression analysis
Human papillomavirus as a viral oncogenic model: oncogenetics mechanisms and analysis techniques
Molecular biology of gastrointestinal tract neoplasms: applications for diagnosis, classification, prognosys and predictivity
Molecular biology of breast neoplasms: applications for diagnosis, classification, prognosys and predictivity
Molecular biology of lung neoplasms: applications for diagnosis, classification, prognosys and predictivity
Classification and molecular diagnosis of soft tissue tumours
Electronic microscopy. Technical principles and applications; electronic microscopy in amyloidosis
Teaching methods
Frontal lessons
Reccomended or required readings
KUMAR M., ABBAS A.K., ASTER J.C. Robbins and Cotran - Pathologic basis of disease - 2 volumes X Edition, 2021
Assessment methods
Oral exam with multiple questions aimed at ascertaining the knowledge acquired on the lessons' topic. The assessment will also take into account the ability to communicate and use an appropriate scientific language.
Sustainable development goals - Agenda 2030
Università di Pavia - Offerta formativa