2021/2022

2021/2022

DM270

BIO/10 (BIOCHEMISTRY)

DEPARTMENT OF PUBLIC HEALTH, NEUROSCIENCE, EXPERIMENTAL AND FORENSIC MEDICINE

OCCUPATIONAL THERAPY

PERCORSO COMUNE

1°

1st semester (04/10/2021 - 21/01/2022)

2

16 lesson hours

Italian

WRITTEN TEST

VISAI LIVIA - 2 ECTS

No particular prerequisite

The main objectives of the course are to train students to understand the chemistry and biochemistry as a preliminary basis for the course of Biochemistry. It is given further emphasis to the main metabolic pathways and their regulation at the molecular level, cellular and tissue and, in order to provide students with the biochemical knowledge to be applied in the practice of health rehabilitation, the arguments are treated by integrating chemical, physiological and pathological human biochemistry.

Introductory Biochemistry: • atomic number, mass number. isotope definition. Atomic theory: structure of atoms according to the atomic theory. • Periodic Table. chemical bonds. intermolecular bonds. Sp hybridization, sp2, sp3. Brute formulas and structure. • States of matter. changes in state. Gas Laws. • Valenza, number of oxidation. chemical nomenclature. Classification of chemical reactions. • Chemical kinetics. Thermochemical. • Solutions, solubility, saturation. Ways of expressing concentrations. Physical properties of the solutions. osmotic pressure. Dialysis membranes. • Chemical equilibrium. • electrolytic dissociation. Definition of acids and bases. Definition of pH. Definition of buffer solution, and mechanism of action. Determination of the pH of a buffer solution and physiologic buffers. • Potential redox. • Outline the main elements and inorganic compounds that have biological importance. • Classification, essential structures and reactions of various classes of organic compounds. Definition and examples of isomerism. Biochemistry • Chemistry of amino acids, amino acids with special function (porphyrins, catecholamines, creatine, histamine, serotonin and melanin), monosaccharides, polysaccharides, lipids, and nucleotides. • The digestion of carbohydrates, lipids, amino acids, and purine and pyrimidine nucleotides. • Proteins: Structure. globular proteins: myoglobin and hemoglobin. Mechanism of action and diseases related to them. Fibrous proteins: collagen and elastin. Structure and related conditions. • Fat-soluble and water soluble vitamins. Coenzymes derived from vitamin and mechanisms of action. • Enzymes: Classification. Mechanism of action: Michaelis-Menten equation. Definition of Km and Vmax. Mechanisms of competitive and non-competitive inhibition. Mechanisms of enzyme regulation. • Bioenergetics and oxidative phosphorylation. Chemioosmotic assumptions and the membrane transport systems. • carbohydrate metabolism: glycolysis, gluconeogenesis, glycogen synthesis and glycogenolysis, the pentose phosphate shunt. main and adjustment stages. • The citric acid cycle (TCA). • Lipid metabolism: fatty acids and triacylglycerols. main and adjustment stages. Cholesterol metabolism and steroids. main and adjustment stages. • Nitrogen Metabolism: nitrogen removal. Degradation and synthesis of amino acids.

The course will take place with oral lectures that will make use of multimedia systems. The instructor will be on hand throughout the duration of the course, by appointment via e-mail (visai.professionisanitarie@unipv.it), to answer questions and support students during their training, even with individual meetings (Friday from 11.00 to 12.00).

no particular texts

The examination of the Biochemistry course includes a written exam in general and inorganic chemistry and organic, the passing of which is crucial to take the written exam in biochemistry. Both written tests will focus on the main topics of the course contents.

no other info