Enrollment year
2020/2021
Academic discipline
MED/15 (BLOOD DISEASES)
Department
DEPARTMENT OF INTERNAL MEDICINE AND THERAPEUTICS
Course
MEDICINE AND SURGERY
Curriculum
PERCORSO COMUNE
Period
2nd semester (27/02/2023 - 26/05/2023)
Lesson hours
24 lesson hours
Activity type
WRITTEN AND ORAL TEST
Prerequisites
The student should have passed the exam of general physiology. Principles of general biology, genetics, general patology and immunology are also required, with particular reference to the mechanisms of cancerogenesis.
Learning outcomes
The student attending this course is expected to acquire fundamental knowledge of the pathophysiology of blood diseases and their clinical features, and to learn basic concepts of therapy. Eventually, he/she should be familiar with the diagnostic approach to the most common conditions.
Course contents
Topics to be covered:
1. Bone Marrow and Peripheral Blood
2. Hematopoietic Stem Cells & Growth Factors
3. Hematologic Alterations:
• Erythropoiesis: Anemia and Polycythemia
• Hemostasis: Bleeding and Thrombosis
• Enlargement of Lymph Nodes & Spleen
• Disorders of Granulocytes and Monocytes
4. Erythron, Erythropoietin, and Classification of anemia
5. Aplastic Anemia
6. Iron Metabolism, Iron Deficiency Anemia and Genetic Hemochromatosis
7. Anemia of Inflammation
8. Megaloblastic Anemias
9. Thalassemia Syndromes
10. Sickle Cell Disease
11. Hemolytic Anemias
12. Myeloproliferative Neoplasms: Chronic Myeloid Leukemia
13. Myeloproliferative Neoplasms: Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis
14. Myeloid Neoplasms: Myelodysplastic Syndromes
15. Myeloid Neoplasms: Acute Myeloid Leukemia
16. Lymphoid Neoplasms: Acute Lymphoid Leukemia
17. Lymphoid Neoplasms: Hodgkin’s Lymphoma
18. Lymphoid Neoplasms: Malignant Lymphomas
19. Lymphoid Neoplasms: Chronic Lymphatic Leukemia
20. Plasma Cell Neoplasms: Monoclonal Gammopathy of Undetermined Significance (MGUS), Multiple Myeloma, and Waldenström's Macroglobulinemia
21. AL Amyloidosis
22. Disorders of Platelets and Vessel Wall:
• Thrombocytopenia (Immune Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, Thrombotic Thrombocytopenic Purpura)
• von Willebrand Disease
23. Coagulation Disorders:
• Hemophilia
• Disseminated Intravascular Coagulation
• Arterial and Venous Thrombosis
• Antiplatelet & Anticoagulant Drugs
24. Transfusion Biology and Therapy
25. Hematopoietic Cell Transplantation
Teaching methods
Lectures, small group teaching, clinical case discussion.
Reccomended or required readings
Harrison's Principles of Internal Medicine
Assessment methods
Exam modalities
The exam consists of a written test and an oral test, both required. The written test includes 60 questions, each with five possible answers and only one correct, to be completed in 120 minutes. In the evaluation of the written test, the following scores are assigned:
• 1 for each correct answer
• 0 for any failure to reply
• -0.25 for each wrong answer
To be admitted to the oral exam, a student must have obtained a minimum of 36/60 in the written test. The final score is a weighted average of written and oral test outcomes.
Exam registration must be done online, while examinations take place in the classroom located in Clinica Ematologica, inside Fondazione IRCCS Policlinico San Matteo.
There are 4 exam sessions in any academic year (January-February, June-July, September, and December), overall with 6 exam dates (2 in January-February, 2 in June-July, 1 in September, and 1 in December).
Further information
Please contact the Clinica Ematologica secretariat for further information:
• Phone: 0382-503084
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