2015/2016

2017/2018

DM270

MED/15 (MALATTIE DEL SANGUE)

DIPARTIMENTO DI MEDICINA MOLECOLARE

MEDICINA E CHIRURGIA (IN LINGUA INGLESE)

PERCORSO COMUNE

3°

Secondo Semestre (05/03/2018 - 08/06/2018)

3

24 ore di attività frontale

English

ORALE

ARCAINI LUCA - 1 CFU
MALCOVATI LUCA - 2 CFU

The student should have passed the physiology exam

The student attending this course is expected to acquire fundamental knowledge of the pathophysiology of blood diseases and their clinical features, and to learn basic concepts of therapy. Eventually, he/she should know the diagnostic approach to most common conditions.

Topics to be covered for exam preparation:

1. Bone Marrow and Peripheral Blood
2. Hematopoietic stem cells & growth factors
3. Hematologic Alterations
• Erythropoiesis: Anemia and Polycythemia
• Hemostasis: Bleeding and Thrombosis
• Enlargement of Lymph Nodes & Spleen
• Disorders of Granulocytes and Monocytes
4. Erythron, erythropoietin, and classification of anemia
5. Aplastic Anemia
6. Iron Metabolism, Iron Deficiency Anemia and Genetic Hemochromatosis
7. Anemia of Inflammation
8. Megaloblastic Anemias
9. Thalassemia Syndromes
10. Sickle cell disease
11. Hemolytic anemias
12. Myeloproliferative Neoplasms: Chronic Myeloid Leukemia
13. Myeloproliferative Neoplasms: Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis
14. Myeloid Neoplasms: Myelodysplastic Syndromes
15. Myeloid Neoplasms: Acute Myeloid Leukemia
16. Lymphoid Neoplasms: Acute Lymphoid Leukemia
17. Lymphoid Neoplasms: Hodgkin’s Lymphoma
18. Lymphoid Neoplasms: Malignant Lymphomas
19. Lymphoid Neoplasms: Chronic Lymphatic Leukemia
20. Plasma Cell Neoplasms: Monoclonal Gammopathy of Undetermined Significance (MGUS), Multiple Myeloma, and Waldenström's Macroglobulinemia
21. AL amyloidosis
22. Disorders of Platelets and Vessel Wall
• Thrombocytopenia (Immune Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, Thrombotic Thrombocytopenic Purpura)
• von Willebrand Disease
23. Coagulation Disorders
• Hemophilia
• Disseminated Intravascular Coagulation
• Arterial and Venous Thrombosis
• Antiplatelet & Anticoagulant Drugs
24. Transfusion Biology and Therapy
25. Hematopoietic Cell Transplantation

Lectures, small group teaching, clinical case discussion

Harrison's Principles of Internal Medicine

Exam modalities

The exam consists of a written test and an oral test, both required. The written test includes 60 questions, each with five possible answers and only one correct, to be completed in 120 minutes. In the evaluation of the written test, the following scores are assigned:

• 1 for each correct answer
• 0 for any failure to reply
• -0.25 for each wrong answer

To be admitted to the oral exam, a student must have obtained a minimum of 36/60 in the written test. The final score is a weighted average of written and oral test outcomes.

Exam registration must be done online, while examinations take place in the classroom located in Clinica Ematologica, inside Fondazione IRCCS Policlinico San Matteo.

There are 4 exam sessions in an academic year (January-February, June-July, September, and December), overall with 6 exam dates (2 in January-February, 2 in June-July, 1 in September, and 1 in December)

Please contact the Clinical Ematologica secretariat for further information:

• phone 0382-527857
• email: alessandra.siviero@unipv.it