KIDNEY PHYSIOLOGY
2018/2019
2019/2020
DM270
BIO/09 (FISIOLOGIA)
DIPARTIMENTO DI MEDICINA MOLECOLARE
MEDICINA E CHIRURGIA (IN LINGUA INGLESE)
PERCORSO COMUNE
PRIMO SEMESTRE (01/10/2019 - 17/01/2020)
3
24 ore di attività frontale
SCRITTO E ORALE CONGIUNTI
BOTTINELLI ROBERTO (titolare) - 3 CFU
The course will teach students the phenomena occurring at molecular, cellular, tissue and organ level which support vital functions. At the end of the course, students will know how the organs and systems of the human body work, how their cooperate, and how their function is controlled to keep homeostasis. What is taught at all level of organisation of the living matter will be pout in the frame of the way the organism works. Students will learn the major correlations between the phenomena occurring in physiologic and pathologic conditions.
Basic Principles of Renal Physiology
Renal Functions
Structure of the Kidneys and Urinary System
Basic Renal Processes
Glomerular Filtration
Tubular Reabsorption
Tubular Secretion
Metabolism by the Tubules
Regulation of Membrane Channels and Transporters
“Division of Labor” in the Tubules
The Concept of Renal Clearance
Micturition
Incontinence
Regulation of Ion and Water Balance
Total-Body Balance of Sodium and Water
Basic Renal Processes for Sodium and Water
Primary Active Na+ Reabsorption
Coupling of Water Reabsorption to Na Reabsorption
Urine Concentration: The Countercurrent Multiplier System
Renal Sodium Regulation
Control of GFR
Control of Na+ Reabsorption
Renal Water Regulation
Osmoreceptor Control of Vasopressin Secretion
Baroreceptor Control of Vasopressin Secretion
The Response to Sweating
Thirst and Salt Appetite
Potassium Regulation
Renal Regulation of K+
Renal Regulation of Calcium and Phosphate Ion
Diuretics
Hydrogen Ion Regulation
Sources of Hydrogen Ion Gain or Loss
Buffering of Hydrogen Ion in the Body
Integration of Homeostatic Controls
Renal Mechanisms
H2CO3 Handling
Addition of New HCO 3 to the Plasma
Renal Responses to Acidosis and Alkalosis
Classification of Acidosis and Alkalosis
Lectures, rehearsal and questions and answers to the class
One of the following books:

Vander's Human Physiology, 14th Edition - McGraw Hill

Ganong's Review of Medical Physiology, 25th Edition - McGraw Hill

Berne & Levy Physiology, 6th Edition - Elsevier
Written text (multiple choices) & oral exam