Adequate understanding of principles of Anatomy, Physiology, Biology and Biochemistry.
The aim of the course is to give information on general principles and molecular aspects on how drugs act, drugs discovery and development, targets for drug action and quantitative aspect of drug–receptors interactions, absorption, distribution and excretion of drugs in the body, pharmacokinetics and therapeutic drug monitoring.
Basic principles of Chemotherapy, Antibacterial drugs, Antiviral drugs and Cancer Chemotherapy.
General principles and molecular aspects on how drugs act. Drugs discovery and preclinical studies. Clinical studies. Pharmacovigilance. Targets for drug action: receptor proteins (receptors classification and molecular structure of receptors); drug-receptor interactions, drug antagonism. Quantitative aspect of drug–receptors interactions. The movement of the drugs molecules across cell barrier and the adsorption and distribution of drugs in the body. Drug metabolism and first-past effect. Renal excretion of drugs. Biliary excretion and enterohepatic circulation. Pharmacokinetics. Therapeutic drug monitoring. Biotech drugs. Harmful effects of drugs: type of adverse drug reaction, drug toxicity.
Antimicrobial agents (beta-lactam antibiotics, agents that interfere with the syntheisi or action of folate, agents affecting bacterial protein synthesis); Antiviral drugs; Drugs used in cancer chemotherapy.
Lectures
Goodman and Gilman's The Pharmacological Basis of Therapeutics Twelfth Edition, New York McGraw-Hill, 2011
Katzung, BG, Master SB, Trevor A J. Basic and Clinical Pharmacology; New York: McGraw-Hill Medical, 2012
Written examination consisting of multiple choice and open questions, primarily based upon the didactic material covered in the course.
Faculty members are available at times reserved for student visits to provide clarifications about topics included in the course.
Università di Pavia - Offerta formativa