PATHOLOGICAL ANATOMY
2013/2014
2015/2016
DM270
MED/08 (ANATOMIA PATOLOGICA)
DIPARTIMENTO DI MEDICINA MOLECOLARE
MEDICINA E CHIRURGIA (IN LINGUA INGLESE)
PERCORSO COMUNE
SECONDO SEMESTRE (07/03/2016 - 27/05/2016)
1
8 ore di attività frontale
ENGLISH
ORALE
PAULLI MARCO - 1 CFU
=
The student attending this course is expected to acquire fundamental knowledge of the pathophysiology of blood diseases and their clinical features, and to learn basic concepts of therapy.
Topics to be covered for exam preparation:

1. Bone Marrow and Peripheral Blood

2. Hematopoietic stem cells & growth factors

3. Hematologic Alterations

• Erythropoiesis: Anemia and Polycythemia

• Hemostasis: Bleeding and Thrombosis

• Enlargement of Lymph Nodes & Spleen

• Disorders of Granulocytes and Monocytes

4. Erythron, erythropoietin, and classification of anemia

5. Aplastic Anemia

6. Iron Metabolism, Iron Deficiency Anemia and Genetic Hemochromatosis

7. Anemia of Inflammation

8. Megaloblastic Anemias

9. Thalassemia Syndromes

10. Sickle cell disease

11. Hemolytic anemias

12. Myeloproliferative Neoplasms: Chronic Myeloid Leukemia

13. Myeloproliferative Neoplasms: Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis

14. Myeloid Neoplasms: Myelodysplastic Syndromes

15. Myeloid Neoplasms: Acute Myeloid Leukemia

16. Lymphoid Neoplasms: Acute Lymphoid Leukemia

17. Lymphoid Neoplasms: Hodgkin’s Lymphoma

18. Lymphoid Neoplasms: Malignant Lymphomas

19. Lymphoid Neoplasms: Chronic Lymphatic Leukemia

20. Plasma Cell Neoplasms: Monoclonal Gammopathy of Undetermined Significance (MGUS), Multiple Myeloma, and Waldenström's Macroglobulinemia

21. AL amyloidosis

22. Disorders of Platelets and Vessel Wall

• Thrombocytopenia (Immune Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, Thrombotic Thrombocytopenic Purpura)

• von Willebrand Disease

23. Coagulation Disorders

• Hemophilia

• Disseminated Intravascular Coagulation

• Arterial and Venous Thrombosis

• Antiplatelet & Anticoagulant Drugs

24. Transfusion Biology and Therapy

25. Hematopoietic Cell Transplantation


ADI: This activity will be conducted by a tutor with a small group of students, and will consist of clinical practice and discussion of clinical cases.
Ah hoc instructions are provided by the Clinical Ematologica secretariat.
=
Reference Textbook: Harrison's Principles of Internal Medicine

Nota bene: several updates of chapters of the Harrison's Principles of Internal Medicine are discussed every year in the formal lectures.
The exam consists of a written test and an oral test, both required. The written test includes 60 questions, each with five possible answers and only one correct, to be completed in 120 minutes. In the evaluation of the written test, the following scores are assigned:



• 1 for each correct answer

• 0 for any failure to reply

• -0.25 for each wrong answer



To be admitted to the oral exam, a student must have obtained a minimum of 36/60 in the written test. The final score is a weighted average of written and oral test outcomes.



Exam registration must be done online, while examinations take place in the classroom located in Clinica Ematologica, inside Fondazione IRCCS Policlinico San Matteo.



There are 4 exam sessions in an academic year (January-February, June-July, September, and December), overall with 6 exam dates (2 in January-February, 2 in June-July, 1 in September, and 1 in December)