At completion of the course, students must be able to:
a) describe and interpret therapeutic and adverse effects induced by medicines on organs and apparatuses;
b) describe and interpret the manifestations induced by exposure to toxins, environmental pollutants and drug overdose, and implement the appropriate preventive and therapeutic actions against toxic reactions;
c) describe and interpret the manifestations induced induce by drug abuse and dependence and implement the appropriate preventive and therapeutic actions against such conditions;
d) assess the risk to benefit ratio of medicines used in the therapeutic setting;
e) select and utilize appropriately the medications used in the most important pathological conditions.
The course includes three main modules (i) pharmacology/clinical pharmacology/ neuropsychopharmacology; (ii) chemotherapy and (iii) toxicology.
Pharmacology, clinical pharmacology and neuropsychopharmacology
Cardiovascular pharmacology: Antianginals; antihypertensives; cardioactive glycosides and other positive inotropic drugs; antiarrhythmics; antidyslipemics; anticoagulants; thrombolytics; antiplatelet drugs; diuretics; drugs for haematological disorders.
Endocrine and metabolic pharmacology: Pituitary hormones; thyroid hormones and antithyroid drugs; adrenocortical hormones; antidiabetics; androgens, estrogens, progestagens and combination products; other contraceptive agents; agents affecting calcium homeostasis; drugs for the treatment of osteoporosis; vitamins.
Autonomic pharmacology: Drugs of the adrenergic and cholinergic systems.
Gastro-intestinal pharmacology: Antiulcer drugs, prokinetics, laxatives, antidiarrhoeics, antiemetics.
Respiratory pharmacology: Antiasthmatics.
Genitourinary pharmacology: Drugs affecting uterine motility; drugs for the treatment of prostatic hypertrophy.
Immunopharmacology and pharmacology of inflammation: Immunomodulators and immunosuppressants; antihistamines; nonsteroidal anti-inflammatory drugs; corticosteroids and other drugs for the treatment of rheumatoid arthritis; antigout drugs; antipyretics.
Neuropsychopharmacology: Antipsychotics; antidepressants; anxiolytics; hypnotics; major analgesics; antiepileptic drugs; antiparkinson drugs; antimigraine drugs; muscle relaxants and other drugs used in the treatment of spasticity; general and local anaesthetics; drugs used for the treatment of dementia and of neurodegenerative disorders.
Beta-lactam antibiotics; aminoglycosides; quinolones; macrolides; lincosamides;
glycopeptides; tetracyclines; cloramphenicol; sulfonamidesi; rifamicins;
antimicobacterial agents and anti-tubercolosis therapy; antimicotics; antivirals;
agents used to treat protozoal infections; antielmintics; antineoplastic agents.
Toxicity affecting organs and apparatuses (liver, kidney, nervous system, respiratory apparatus, reproductive system); alcoholism and alcohol-related disorders;
acute intoxications (toxic gases, mushrooms agricultural products, household products, psychoactive drugs, principles applied in diagnostics and management);toxicological risks during pregnancy, poisoning in special situations (childhood and old age); drug abuse and dependence. Toxic effects of environmental pollutants.
The course includes formal and interactive lectures. Faculty members are available at times reserved for student visits to provide clarifications about topics included in the course.
Conforti A, Cuzzolin L, Leone R, Moretti U, Pignataro G, Taglialatela M, Vanzetta M. Farmacologia per le professioni sanitarie, Ed. Sorbona, 2015
Furlanut M. Farmacologia. Principi e applicazioni. Ed Piccin, 2013
Goodman and Gilman's The Pharmacological Basis of Therapeutics (Laurence Brunton, Bruce Chabner, Bjorn Knollman, authors), Twelfth Edition, New York McGraw-Hill, 2011
Harvey RA, Clark MA, Finkel R, Rey JA, Whalen, K. Lippincott’s illustrated reviews: Pharmacology, 5th Edition, Lippincott, Williams & Wilkins), 2011
Katzung, BG, Master SB, Trevor A J. Basic and Clinical Pharmacology; New York: McGraw-Hill Medical, 2012
Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics, 3rd edition. W. B. Saunders, London, 2009
The Pharmacology II examination consists in an oral evaluation addressing the topics included in the different modules. Oral or written in itinere evaluations may be conducted within each module. Students must demonstrate that they achieved the learning objectives of the course.
The final score of the examination is calculated based on the weighed mean of evaluations concerning the learning objectives associated with each module.