GENERAL PHARMACOLOGY AND PHARMACODYNAMICS
2014/2015
2016/2017
DM270
BIO/14 (FARMACOLOGIA)
DIPARTIMENTO DI MEDICINA MOLECOLARE
MEDICINA E CHIRURGIA (IN LINGUA INGLESE)
PERCORSO COMUNE
PRIMO SEMESTRE (03/10/2016 - 13/01/2017)
2
20 ore di attività frontale
English
ORALE
VAIRETTI MARIAPIA (titolare) - 2 CFU
The aim of the course is to give information on general principles and molecular aspects on how drugs act, drugs discovery and development, targets for drug action and quantitative aspect of drug–receptors interactions, absorption, distribution and excretion of drugs in the body, pharmacokinetics and therapeutic drug monitoring.
General principles and molecular aspects on how drugs act. Drugs discovery and preclinical studies. Clinical studies. Pharmacovigilance. Targets for drug action: receptor proteins (receptors classification and molecular structure of receptors); drug-receptor interactions, drug antagonism. Quantitative aspect of drug–receptors interactions. The movement of the drugs molecules across cell barrier and the adsorption and distribution of drugs in the body. Drug metabolism and first-past effect. Renal excretion of drugs. Biliary excretion and enterohepatic circulation. Pharmacokinetics. Therapeutic drug monitoring. Biotech drugs. Harmful effects of drugs: type of adverse drug reaction, drug toxicity.
The course includes formal and interactive lectures. Faculty members are available at times reserved for student visits to provide clarifications about topics included in the course.
Goodman and Gilman's The Pharmacological Basis of Therapeutics (Laurence Brunton, Bruce Chabner, Bjorn Knollman, authors), Twelfth Edition, New York McGraw-Hill, 2011
Harvey RA, Clark MA, Finkel R, Rey JA, Whalen, K. Lippincott’s illustrated reviews: Pharmacology, 5th Edition, Lippincott, Williams & Wilkins), 2011
Katzung, BG, Master SB, Trevor A J. Basic and Clinical Pharmacology; New York: McGraw-Hill Medical, 2012
Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics, 3rd edition. W. B. Saunders, London, 2009
Written examination consisting of forty questions primarily based upon the didactic material covered in the course.