CLINICAL BIOCHEMISTRY
2012/2013
2014/2015
DM270
BIO/12 (BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA)
DIPARTIMENTO DI MEDICINA MOLECOLARE
MEDICINA E CHIRURGIA (IN LINGUA INGLESE)
PERCORSO COMUNE
SECONDO SEMESTRE (23/02/2015 - 22/05/2015)
5
40 ore di attività frontale
ENGLISH
ORALE
MERLINI GIAMPAOLO - 5 CFU
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LABORATORY MEDICINE

Laboratory medicine is the science that underpins the practice of medicine. Observation and good basic scientific method have led to the discovery and understanding of biomarkers. The course will focus on the utility of biomarker measurement in the practice of medicine, through their potential use for screening, diagnosis, prognosis and guiding treatment. This knowledge is used to deliver improved outcomes for patient care. Updated consensus papers and guidelines on the best use of laboratory test in clinical practice will be discussed.

CLINICAL MICROBIOLOGY

Clinical Microbiology introduces basic principles and then applies clinical relevance in four segments of the academic preparation for physicians: immunology, bacteriology, mycology, and virology. (Parasitology is covered with seminars held by Prof.E.Brunetti.) This course includes many etiological agents responsible for global infectious diseases. Because the territory covered by infections and the immune response expands each year, we focus on pathogenic mechanisms in order to foster a student’s ability to solve problems in their future clinical career.
LABORATORY MEDICINE

Please see the lesson schedule reported below.

Suggested textbooks: The slides will be provided and are adequate for the preparation of the examination.

Textbooks may be used for consultation and are available through the teacher:

Laposata M, Laboratory Medicine: The diagnosis of disease in the clinical laboratory – McGraw-Hill – 2010

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5e, Elsevier, December 2011

Salvatore F, Biochimica Umana con schede cliniche, Idelson-Gnocchi, 2013

Lessons

1. Introduction to Laboratory Medicine, Preanalytical phase and errors

2. Diagnostic performances, ROC curve, use of reference values and decision values, quality management

3. Plasma, serum, and plasma proteins: their best use in clinical practice

4. Monoclonal gammapathies and protein misfolding diseases

5. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors

6. Flow cytometry and blood count

7. Diabetes: diagnosis follow up and assessment of end organ damage

8. Liver and pancreatic function

9. Renal function and urinalysis

10. Electrolytes and blood gasses: a practical approach

11. Biomarkers of cardiac damage and dysfunction – New criteria for AMI

12. Biomarkers in oncology, problems and pitfall

13. Assessing thrombotic and bleeding risk: a practical approach

14. Nutritional assessment – Calcium metabolism - Markers of bone metabolism

15. Autoimmunity: laboratory assessment

16. Thyroid function – Pregnancy

17. Pharmacogenetics

18. Proteomics, metabolomics: a perspective

CLINICAL MICROBIOLOGY

Upper espiratory tract infections

Lower respiratory tract Infections

Sirs,Sepsis and Fever of unknown origin

CNS infections

Hepatitis

Gastrointestinal infections

ToRCH Complex

HIV and Sexually transmitted diseases

PARASITOLOGY SEMINARS ( Prof.Brunetti)

Amebiasis

Chagas

Cisticercosis

Cryptospordiosis

malaria

toxocara

Trematodes - Nematodes

Tripanosomiasis



LABORATORY MEDICINE
A program of the ADI will be presented at the beginning of the course. Opportunities for developing personal interests of individual students will be offered.
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will be based on the oral exam in which students must demonstrate to have studied and understood the topics of the program