PHARMACODYNAMICS
2013/2014
2015/2016
DM270
BIO/14 (FARMACOLOGIA)
DIPARTIMENTO DI MEDICINA MOLECOLARE
MEDICINA E CHIRURGIA (IN LINGUA INGLESE)
PERCORSO COMUNE
PRIMO SEMESTRE (07/09/2015 - 02/10/2015)
1
8 ore di attività frontale
ENGLISH
ORALE
VAIRETTI MARIAPIA - 1 CFU
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The aim of the course is to give information on general principles and molecular aspects on how drugs act, drugs discovery and develpment, targets for drug action and quantitative aspect of drug–receptors interactions, adsorption, distribution and excretion of drugs in the body, pharmacokinetics and therapeutics drug monitoring.
General principles and molecular aspects on how drugs act. Drugs discovery and preclinical studies. Clinical studies. Pharmacovigilance. Targets for drug action: receptor proteins (receptors classification and molecular structure of receptors); drug-receptor interactions, drug antagonism. Quantitative aspect of drug–receptors interactions. The movement of the drugs molecules across cell barrier and the adsorption and distribution of drugs in the body. Drug metabolism and first-past effect. Renal excretion of drugs. Biliary excretion and enterohepatic circulation. Pharmacokinetics. Therapeutics drug monitoring. Biotech drugs. Harmful effects of drugs: type of adverse drug reaction, drug toxicity.
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Written examination consisting of forty questions primarily based upon the didactic material covered in the course.